Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling
期刊名：Journal of Asian Natural Products Research
文献编号：
文献地址： https://www.tandfonline.com/doi/abs/10.1080/10286020.2020.1821669
发表日期：25 Nov 2020
文献编号：
文献地址： https://www.tandfonline.com/doi/abs/10.1080/10286020.2020.1821669
发表日期：25 Nov 2020
AbstractDecursin, a coumarin compound isolated from Angelica gigas has been shown to possess multiple anti-tumor activities. But it’s still little known about the effects associated with cervical cancer. To explore the anti-tumor role of decursin and gain insights into its underlying mechanisms, we analyzed proliferation in parallel with apoptosis and migration in HeLa cells. Our findings implied that decursin can provoke apoptosis, and inhibit cell proliferation, migration in HeLa cells. More importantly, decursin also inhibited the tumor growth in vivo. The mechanisms may be associated with the regulation of Akt activation, with implications for novel therapeutic strategies on cervical cancer.
… potential applications for decursin in cervical cancer. 4. Experimental. 4.1. Chemicals and reagents. Decursin (Purify: HPLC > 95%) was obtained from Chengdu Biopurify (Chengdu, China). The Annexin-V FITC/PI cell apoptosis …
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