Optimization of enzyme-assisted extraction of ginsenoside Rb1 from Vietnamese Panax notoginseng (BURK.) F.H. Chen roots and anticancer activity examination of the extract
期刊名：Separation Science and Technology
文献编号：
文献地址： https://www.tandfonline.com/doi/abs/10.1080/01496395.2020.1795676
发表日期：30 Jul 2020
文献编号：
文献地址： https://www.tandfonline.com/doi/abs/10.1080/01496395.2020.1795676
发表日期：30 Jul 2020
ABSTRACTIn this study, the conditions of ginsenoside Rb1 extraction from Panax notoginseng (Burk.) F.H. Chen (P. notoginseng) roots by enzyme-assisted method were investigated by using the central composite design (CCD). This design was applied to survey the effects of pH, temperature, and time on Rb1 content. The concentration of Rb1 was determined based on high-performance liquid chromatography (HPLC). The investigation of anticancer activities of P. notoginseng extract on breast carcinoma (MCF-7) cell lines and human lung carcinoma (Lu) showed that the extract had remarkable cytotoxic activity against these cancer cell lines.
… Materials and methods. Materials and chemicals. Vietnamese P. notoginseng roots were purchased from Lao Cai Province, Vietnam. The reference standard of Rb1 was purchased from Chengdu Biopurify Phytochemicals Ltd., China …
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