Abstract
Ethnophamacological relevance
Sam So Eum (SSE), used in traditional Korean medicine, has been prescribed for the treatment of various ailments including emesis, and fever for centuries. SSE is known by several different names (Shen Su Yin in traditional Chinese medicine; Jin So In traditional Japanese Kampo medicine). It is a mixture of medicinal plants including Panax ginseng C. A. Mey., Perilla frutescens (L.) Britton, and Peucedanum praeruptorum Dunn. Studies have revealed that SSE has many pharmacological effects including anti-inflammatory, anti-cancer, and anti-allergic properties, but its toxic effects have not been evaluated in vivo. Recently, the use of traditional medicinal herbs to treat various diseases has increased, owing to increased number of studies supporting their efficacy. However, safety evaluations for toxicity and other adverse effects have not been extensive. It is commonly considered that natural products extracted from traditional medicinal herbs are safer than synthetic drugs, but this lacks a scientific basis. Thus, in this study, we evaluated the toxicity of SSE in male and female rats.
… In Table 13, compound 1, 3, 4, 9–11, 13, 17, 19 (Sigma, St Louis, MO, USA), 12, 14
(Chromadex, California, USA), 8Peucedanol (Biopurify, chengdu, china), 2, 18 (Chemfaces, Wuhan, China >98%), 5–7, 15, 16, 20 (KFDA, Korean). Methanol …
