Corresponding author: KaiQun Ren

Abstract

Casticin is one of the main components of the fruits of Vitex rotundifolia L. Studies have shown that casticin inhibits the growth of various cancer cells, including colon cancer. In the present study, the anticarcinogenic effects of casticin on human colon cancer and the underlying mechanisms were investigated. The results revealed that casticin significantly induced apoptosis of HT29, HCT116, SW480 and Caco2 cells, induced the accumulation of reactive oxygen species (ROS) and increased the protein levels of 

 Casticin was purchased from Biopurify Phytochemicals Ltd. (Chengdu, China). ...