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文献信息

Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells

期刊名：EXP THER MED.
文献编号：
文献地址： http://www.spandidos-publications.com/etm/8/5/1494?text=fulltext
发表日期： 2014 Aug.26.

Authors: Lin Qu;FengXia Liu;XiaoCheng Cao;Qiao Xiao;Xiaohong Yang;KaiQun Ren

Corresponding author: KaiQun Ren

Abstract

Casticin is one of the main components of the fruits of Vitex rotundifolia L. Studies have shown that casticin inhibits the growth of various cancer cells, including colon cancer. In the present study, the anticarcinogenic effects of casticin on human colon cancer and the underlying mechanisms were investigated. The results revealed that casticin significantly induced apoptosis of HT29, HCT116, SW480 and Caco2 cells, induced the accumulation of reactive oxygen species (ROS) and increased the protein levels of

Casticin was purchased from Biopurify Phytochemicals Ltd. (Chengdu, China). ...