Abstract
Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromatography, coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry, was established for the rapid separation and sensitive identification of the chemical components in QXQM and its metabolites in serum of rats. Seventy‐two compounds were systematically identified in QXQM, including flavonoids, terpenoids, anthraquinones, phenylethanoid glycosides, stilbenes, alkaloids, and organic acids. Thirteen prototype compounds and 29 metabolites were detected in the serum of rats. The results provided fundamental information for further studying the mechanisms and clinical application of QXQM.
… National Institutes for Food and Drug Control (Beijing, China); rehmannioside A was purchased from Chengdu Biopurify Phytochemicals (Sichuan, China); epimedin A, epimedin B, epimedin C, icariin, sagittatoside B, 2''-O-Rhamnosylicariside …
Analysis of the chemical components of Qixianqingming granules and their metabolites in rats by UPLC‐ESI‐Q‐TOF‐MS
期刊名：Journal of Mass Spectrometry
文献编号：
文献地址： https://onlinelibrary.wiley.com/doi/abs/10.1002/jms.4484
发表日期：30 November 2019
文献编号：
文献地址： https://onlinelibrary.wiley.com/doi/abs/10.1002/jms.4484
发表日期：30 November 2019
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