Obesity and hyperlipidemia are a major problem in the world. Pluchea indica (L.) Less. tea (PIT) is a beverage that has various indications. Tis study focused on the efect of the PIT on inhibiting adipogenesis of 3T3-L1 cells and pancreatic lipase enzyme activity. Te viability of 3T3-L1 cells was not signifcantly decreased afer exposure to 200 to 1000 �g mL−1 PIT compared to controls (� > 0.05). Te PIT at 750 to 1000 �g mL−1 exhibited a signifcantly reduced lipid accumulation compared to the control (� < 0.05). Te inhibitory efects of the PIT at 250 to 1000 �g mL−1 on lipase activity were signifcantly increased compared to control (� < 0.05). Te FTIR results showed that the integrated areas of lipids, proteins, nucleic acids, glycogen, and carbohydrates of the PIT-treated 3T3-L1 adipocytes were signifcantly lower than the untreated 3T3-L1 adipocytes (� < 0.05). Tese fndings may indicate that the PIT is not only capable of inhibiting lipids and carbohydrate accumulation in adipocytes but also has a potential to inhibit pancreatic lipase activity. So, the PIT may be further developed to the novel lipid-lowering herbal supplement for the management of overweight or obesity
… 4-O-caffeoylquinic acid (4-CQ), 5-O-caffeoylquinic acid (5-CQ), 3,4-O-dicaffeoylquinic acid (3,4-CQ), 3,5-O-dicaffeoylquinic acid (3,5-CQ), and 4,5-O-dicaffeoylquinic acid (4,5-CQ) were purchased from Chengdu Biopurify Phytochemicals Ltd., (Sichuan, China) …
