Heme oxygenase 1-mediated novel anti-inflammatory activities of Salvia plebeia and its active components
Muhammad Akram, Ahmed Shah Syed, Kyeong-A Kim, Jong Soo Lee, Sun-Young Chang, , Chul Young Kim, , Ok-Nam Bae, ,
Abstract
Ethnopharmacological relevance
Salvia plebeia R. Br. (SP) has been widely used as a traditional folk medicine for the treatment of infectious diseases and pain. An anti-inflammatory potential of SP has remains largely unknown.
Aim of the study
We tried to elucidate the principle mechanism and the active ingredients underlying the anti-inflammatory activities of SP.
Materials and Methods
We investigated the protective activities of SP methanolic extract (SPME) and seven representative ingredients against inflammation. Quantitative analysis
The standard compounds luteoloside, nepitrin, homoplantagenin, luteolin, nepetin, hispidulin, and eupatorin were purchased from Chengdu Biopurify Phytochemicals Ltd (Chengdu, China).