Abstract
Coreopsis tinctoria flowers, a well-known medicinal and edible plant, have been reported to possess antioxidant and anti-inflammatory activities. However, its protective effects and underlying mechanisms on liver injury remain unclear. The aim of this study was to investigate the underlying mechanisms by which Coreopsis tinctoria flowers phenolic extract (CTP) alleviated D-galactosamine andlipopolysaccharide (D-GalN/LPS) induced acute liver injury in mice. Our results showed that pretreatment with CTP improved liver histology while decreased levels of serum aminotransferase and malondialdehyde. CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARα), and peroxisome proliferator-activated receptor gamma (PPARγ). In conclusion, results suggested that CTP protected against D-GalN/LPS -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ.
… (Preland, TX, USA). Polyphenol standards (purity ≥ 98%) including chlorogenic acid,caffeic acid, vanillic acid, orientin, rutin, hypericin were purchased from Chengdu Biopurify Phytochemicals (Chengdu, China). All other chemicals were of analytical grade. 2.2 …
Protective effects of Coreopsis tinctoria flowers phenolic extract against D-galactosamine/lipopolysaccharide -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ
期刊名：Food and Chemical Toxicology
文献编号：
文献地址： https://doi.org/10.1016/j.fct.2018.09.026
发表日期：21 September, 2018
文献编号：
文献地址： https://doi.org/10.1016/j.fct.2018.09.026
发表日期：21 September, 2018
