在线咨询
联系电话:
销售：
400-829-7929（7*24小时）
028-
82633860
028-
82633397
028-82633165
技术服务和产品定制：
028-82633987
在线服务:
沈帅 
文静
贺丹丹
文献信息
Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization
The pharmacological activities of many Punica granatum L. components suggest a wide range of clinical applications for the prevention and treatment of diseases where chronic inflammation is believed to play an essential etiologic role. The current work reports a case study analyzing the effect produced by a magistral formulation of ethanolic extracts of Punica granatum peels on a non-healing chronic ulcer. The complete closure of the chronic ulcer that was initially not responsive to standard medical care was observed. A 2% (w/w) P. granatum peels ethanolic extract hydrogel-based formulation (PGHF) was standardized and subjected to physicochemical studies to establish the quality control parameters using, among others, assessment criteria such as optimum appearance, pH range, viscosity and hydrogel disintegration. The stability and quantitative chromatographic data was assessed in storage for six months under two temperature regimes. An efficient HPLC-DAD method was established distinguishing the biomarkers punicalin and punicalagin simultaneously in a single 8 min run. PGHF presented suitable sensorial and physicochemical performance, showing that punicalagin was not significantly affected by storage (p > 0.05). Formulations containing extracts with not less than 0.49% (w/w) total punicalagin might find good use in wound healing therapy.
... guaranteed effectiveness and safety. 4. Materials and Methods. 4.1. Chemicals.
Punicalin and punicalagin standards were obtained from Biopurify Pharmaceuticals
Ltd. (Chengdu, China), purity over 98%. HPLC-grade solvents ...
