Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease

Jingjing Wang, Xiaoqing Chen, Wei Wang, Yating Zhang, Ziying Yang, 

Yu Jin, Hui Ming Ge, Erguang Li , Guang Yang , 

Abstract

Ethnopharmacological relevance

The radices of Glycyrrhiza uralensis Fisch. and herbal preparations containing Glycyrrhizaspp. have been used for thousands of years as an herbal medicine for the treatment of viral induced cough, viral hepatitis, and viral skin diseases like ulcers in China. Glycyrrhizic acid (GA) is considered the principal component in Glycyrrhiza spp. with a wide spectrum of antiviral activity.

Aim

The present study attempt to validate the medicinal use of Glycyrrhiza uralensis for hand, foot and mouth disease (HFMD) and further to verify whether GA is an active antiviral component in the water extract of Glycyrrhiza uralensis.

Liquiritin was from Chengdu Biopurify Pharmaceuticals (Chengdu)