Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

Mee-Young Lee, In-Sik Shin, Woo-Young Jeon, Chang-Seob Seo, Hyekyung Ha,Jung-Im Huh, Hyeun-Kyoo Shin , 

Abstract

Ethnopharmacological evidence

Oxidative stress plays an important role in the pathogenesis of ethanol-induced acute gastric mucosal injury. Bojungikki-tang (Hochuekkito in Japanese, Bu-zhong-yi-qi-tang in Chinese) is a traditional herbal formula used in Korea, Japan, and China to treat allergic diseases and gastrointestinal disorders. However, the mechanism responsible for its actions has not been investigated experimentally.

Aim of the study

The aims of this study were to investigate whether Bojungikki-tang water extract (BJITE) has protective effects against ethanol-induced acute gastric injury in rats and to perform an acute toxicity study to evaluate its safety.

Hesperidin and glycyrrhizin were purchased from Chengdu Biopurify Phytochemicals Ltd (Chengdu, China)