Alpha-Mangostin Potency To Improve Renal Function And Histopathological
Images In High-Fat Diet Rats. This study aimed to study whether alpha-mangostin
could protect the kidneys of high-fat diet rats using the creatinine serum level and
histopathological changes as parameters. The in vivo experimental study with a
completely randomized design used 30 male Sprague Dawley rats. After 7 days of
adaptation, they were randomly divided into six treatment groups, each with five
replications. The study was done for four weeks: NC group (given standard pellet
without treatment for four weeks), five other groups were given a high-fat diet for
four weeks, and at the last two weeks were added with aquadest, corn oil, alpha-
mangostin dose-1, alpha-mangostin dose-2, and simvastatin, namely PTL, CO, D1,
D2, and Sim group. Creatinine level was examined at the end of week 2 and week
4; the difference percentage was analyzed using ANOVA/Kruskal Wallis (α=0.05)
and continued with Duncan/Mann Whitney. It was shown that creatinine level
decreased in D1/D2 = PTL mice (p>0,05); kidney histopathological image in D1 was
better than PTL (p<0,05). It was concluded that the alpha-mangostin kidney
protection effect was not yet visible according to creatinine level, but it was visible
according to histopathological image; further studies are needed.